History of the Hematology Analyzer
In the early 20th century, Molderan used photoelectric apparatus for blood cell counting.in 1947, Rag Krantz used high-efficiency photomultiplier tubes coupled with photoelectric scanning technology and dark field illumination method for blood cell detection and analysis.
This overcame the problems in Molderan’s photoelectric method and could be tried out in the clinic. In 1958, Coulter used the combination of resistivity change and electronic technology on the basis of his predecessors to develop.
In the 1960s, various types of hematology analyzers based on the Coulter principle were developed and widely used, gradually replacing the traditional microscope routine.
Since the 1990s, some scholars have been classifying cells according to the structural differences between naive and mature cell membranes, especially for the detection of naive cells, opening up a new field for blood cell counters.
What is a Hematology Analyzer ?
The number of cells in the human body is within a constant range, and the presence of these cells ensures the normal growth and development of the body.
The hematology analyzer is used for the high speed and accurate detection of various blood cell counts, leukocyte classification and hemoglobin content to provide qualitative and quantitative analysis of the blood components. It also provides relevant information by which the body can be scrutinized.
The hematology analyzer is used to detect a range of pathological conditions which include:
- Anemia
- Hematological disorders (red blood cell disorders
- White blood cell disorders
- Bleeding disorders
- Bone marrow disorders)
- Infections
- hematological malignancies
In addition, the analyser is used for cancer patients receiving chemotherapy. The automated hematology analyser provides critical information immediately, which will improve the patient’s outcome. The choice of analyzer-based equipment is critical to obtaining accurate and automated CBC test results in a variety of settings.
Classification of Hematology Analyzers
Hematology analyzers are mainly classified as 3-part hematology analyzers and 5-part hematology analyzers.
The 3-part hematology analyzer analyzes blood components by measuring the content of red blood cells, white blood cells and platelets.
The 3-part cell counter reports only 3 types of white blood cells (neutrophils, lymphocytes and monocytes) and is used in a wide range of clinical applications, mainly in small laboratories, small clinics, small public hospitals and doctors’ offices.
The 5-part hematology analyzer is designed to measure the level of red blood cells, white blood cells and platelets in the blood and at the same time to subdivide the white blood cells, the five-category cell counter can distinguish between all types of white blood cells (neutrophils, lymphocytes, basophils, eosinophils and monocytes).
The ability to analyze abnormal samples allows for a more detailed and targeted assessment of blood conditions. Thus greatly improving the accuracy and efficiency of the test. It is suitable for use in specialist medical laboratories, public hospitals with large sample volumes, etc.
3-Part Hematology Analyzer Vs 5-Part Hematology Analyzer
The 3-part hematology analyzer uses the principle of resistance to detect the number and volume distribution of white blood cells, red blood cells and platelets, and the colorimetric method to measure the concentration of hemoglobin.
It can detect 21 parameters and two histograms, and the maximum detection speed is 60 samples/hour.
The detection methods include venous whole blood, peripheral whole blood and pre-dilution; the reagents are stored at room temperature, and most of the reagents are open systems that can be used by different manufacturers.
In addition, the triple hematology analyzer also has intelligent functions: anti-arrest function, networking function, blockage removal function, cleaning function, maintenance function, and alarm function.
WBC 5-part hematology analyzer is a dual-channel, five-differential blood analyzer, which uses semiconductor laser scattering, flow cytometry and cytochemical staining to achieve accurate five-differential white blood cell detection, detects 21 parameters, and can display two histograms graph and two scatterplots.
Compared with the three types of blood analyzers, there are some special items that can be tested: CRP, RET, SAA, etc., including a variety of printing. The maximum test speed is 60 samples per hour, and manual and automatic sampling can be selected.
Reagents need to be stored at room temperature, and most of the five types are closed systems, that is, only factory-produced reagents can be used; detection modes are divided into three modes: venous whole blood, terminal whole blood and pre-dilution.
The five types of blood cell analyzers also have intelligent functions: anti-lock, networking, blocking, cleaning, maintenance, and alarm functions.
How to Maintain a Hematology Analyzer?
As a hematology analyzer can be expensive to replace, it is important to know how to maintain it. It is an investment that can pay for itself many times over.
- Use an inverter with a grounded plug to power the hematology analyzer.
- Allow good air circulation around the unit (15 inches from the wall).
- Wait approximately 10 minutes after switching on the analyzer before using it.
- Check for air bubbles in the reagent tube.
- Always check for reagent leaks in the hydraulic circuit.
- Check for air or vacuum leaks in the circuit.
- Avoid abrupt shutdowns.
- Mix the sample thoroughly before use.
- Avoid dust contamination of reagents.
- Use the controls to control your CBC instrument daily.
- Always follow the shutdown procedure.
- Clean the instrument housing regularly.
- Clean the equipment with distilled water before and after analysis.
- Clean the equipment with the recommended cleaning solution.
- Wipe off any blood stains.
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